Over the last decade in treatment of erectile dysfunction, a problem faced by hundred millions men worldwide, have been achieved appreciable successes. Nowadays effective oral preparations are accessible for treatment of the erection disturbances belonging to pharmacological group of phosphodiesterase inhibitors of 5th type. This review is devoted to the different characteristics, including comparative efficiency of one of these preparations - Cialis online. In February 2003 it was approved for clinical use in Europe. Tadalafil has all the advantages of phosphodiesterase inhibitors of 5th type, and also has a number of unique properties. In particular, one of the main advantages of the tadalafil is considered a long period of excretion (17,5 hours), providing long lasting effect of the preparation (36 hours and more). Preparation is presented in the form of tablets, it is available in dosage - 10, 20, 40, 60 mg. Cialis should be taken no more than once a day and unlike sildenafil the fatty food does not affect the pharmacokinetics. Tadalafil, as other phosphodiesterase inhibitors of 5th type, can not be combined with receiving of nitrate.
Cialis online efficiency is very high. For the integrated analysis of 11 randomized, placebo-controlled studies, involving a total of 2012 patients with erectile dysfunction it was shown that the relative frequency of successful attempts at sexual intercourse after taking Cialis in doses of 20 and 40 mg has reached 61 and 72%, and accordingly, taking in placebo group this indicator was 34%. About improvement of the erection quality as a result of taking Cialis online reported 84% of patients. In total 54% of patients during treatment had indicators of the International index of erectile function more than 26 which is equivalent to the normal range. Considering the long period of tadalafil, appreciable interest represents also its efficiency to different terms from the moment of use. This question has been studied in the framework of the generalized analysis of 5 randomized, placebo-controlled, double-blind researches involving in total 1112 patients. Clinical efficiency Cialis online was growing within first 4 hours after its use and remained at high level throughout one and a half days. Main by-effects of tadalafil are the headache (12%-15%), dyspepsia (7-8%) and backaches (5-6%). Cessation of Cialis due of by-effects of 1,6% of the patients taking it in a dose of 10 mg, and 3,2% of patients - in a dose of 20 mg.
Efficiency tadalafil in groups of seriously ill patients also is high, reaching among 64% of people with diabetes, and among 41 % which have transferred a radical prostatectomy. Thus, high clinical efficiency Cialis online is not in doubt. However availability in the market of three various preparations phosphodiesterase 5 types does of inhibitors group an actual problem of choice of most suitable of them for each concrete patient. At once we will notice that the convincing data that one of preparations considerably surpasses others in efficiency it is not received. According to results of the generalised analysis the average of successful sexual intercourses at application sildenafil, vardenafil, tadalafil and placebo has constituted 69, 68, 69 and 33-35,5 % accordingly. Erection improvement was noted at 75-90% of the men who used phosphodiesterase inhibitors of 5th type. It is necessary to underline that these results are received not as a result of direct comparison of preparations, and according to researches of efficiency each of them separately. Nevertheless these indicators are based on the data received at inspection of thousand of patients in well planned researches, and it is possible to consider them highly authentic.
Data presented below have been confirmed in large-scale open European study (Erectile Dysfunction Observational Study, EDOS), which involved 8047 men. Study participants initially received one of three phosphodiesterase inhibitors of 5th type, the purpose of the study was to analyze the event of a change of the patient a drug that group to another within 6 months of observation. Thus 89% of the men who have begun treatment with tadalafil, have continued its using till the end of research while among using sildenafil and vardenafil this indicator has constituted 63-64%, patients that used Cialis online, not only changed it for other preparation much less often, but in 25 percent of cases later again came back to the use of tadalafil. Among the men who changed sildenafil and vardenafil, the given indicator was less than 10%.
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